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 H. Yang, D. Chen, Q.C. Cui, X. Yuan, and Q.P. Dou, “Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome viagra cialis online pharmacy pharmacy and suppresses human prostate cancer growth in nude mice,” Cancer Research, vol. 66, May. 2006, pp. 4758-4765. DOWNLOAD 

C. Cleren, N.Y. Calingasan, J. Chen, and M.F. Beal, “Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity,” Journal of Neurochemistry, vol. 94, Aug. 2005, pp. 995-1004. DOWNLOAD 

M. Nagase, J. Oto, S. Sugiyama, K. Yube, Y. Takaishi, and N. Sakato, “Apoptosis Induction in HL60 and Inhibition Topoisomerase II by Tripterine Celastrol,” Biosch Biotecnol. Biochem, vol. 9, 2003, pp. 1883 - 1887. DOWNLOAD 

D.W. Pyatt, Y. Yang, B. Mehos, A. Le, W. Stillman, and R.D. Irons, “Hematotoxicity of the chinese herbal medicine Tripterygium wilfordii hook f in CD34-positive human bone marrow cells,” Molecular Pharmacology, vol. 57, Mar. 2000, pp. 512-518. DOWNLOAD 

Y. Zhou and Y. Huang, “Antiangiogenic effect of celastrol on the growth of human glioma: an in vitro and in vivo study,” Chin.Med.J, vol. 14, 2009, pp. 1666-1673. DOWNLOAD 

D. Zhang, A. Marconi, L. Xu, C. Yang, G. Sun, X. Feng, C. Ling, W. Qin, G. Uzan, and P. d'Alessio, “Tripterine inhibits the expression of adhesion molecules in activated endothelial cells,” Journal of Leukocyte Biology, vol. 80, Aug. 2006, pp. 309-319. DOWNLOAD 

X. Tao, J.J. Cush, M. Garret, and P.E. Lipsky, “A phase I study of ethyl acetate extract of the chinese antirheumatic herb Tripterygium wilfordii hook F in rheumatoid arthritis,” The Journal of Rheumatology, vol. 28, Oct. 2001, pp. 2160-2167. DOWNLOAD

When Is A Placebo Not A Placebo?

When Is A Placebo Not A Placebo?

Irving Kirsch, best known for that 2008 meta-analysis allegedly showing that "Prozac doesn't work", has hit the headlines again.

This time it's a paper claiming that something does work. Actually Kirsch is only a minor author on the paper by Kaptchuck et al: Placebos without Deception.

In essence, they asked whether a placebo treatment - a dummy pill with no active ingredients - works even if you know that it's a placebo. Conventional wisdom would say no, because the placebo effect is driven by the patient's belief in the effectiveness of the pill.

Kaptchuck et al took 80 patients with Irritable Bowel Syndrome (IBS) and recruited them into a trial of "a novel mind-body management study of IBS". Half of the patients got no treatment at all. The other half got inert cellulose capsules, after having been told, truthfully, that the online pharmacy contained no active drugs but also having been told to expect improvement in a 15 minute briefing session on the grounds that

placebo pills, something like sugar pills, have been shown in rigorous clinical testing to produce significant mind-body self-healing processes.

Guess what? The placebo group did better than the no treatment group, or at least they reported that they did (all the outcomes were subjective). The article has been much blogged about, and you should read those posts for a more detailed and in some cases skeptical examination, but really, this is entirely unsurprising and doesn't challenge the conventional wisdom about placebos.

The folks in this trial believed in the possibility that the pills would make them feel better. They just wouldn't have agreed to take part otherwise. And when those people got the treatment that they expected to work, they felt better. That's just the plain old placebo effect. We already know that the placebo effect is very strong in IBS, a disease which is, at least in many cases, psychosomatic.

So the only really new result here is that there are people out there who'll believe that they'll experience improvement from sugar pills, if you give them a 15 minute briefing about the "mind-body self-healing" properties of those pills. That's an interesting addition to the record of human quirkiness, but it doesn't really tell us anything new about placebos.

Kaptchuk, T., Friedlander, E., Kelley, J., Sanchez, M., Kokkotou, E., Singer, J., Kowalczykowski, M., Miller, F., Kirsch, I., & Lembo, A. (2010). Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome PLoS ONE, 5 (12) DOI: 10.1371/journal.pone.0015591

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Textbook of Tinnitus, 1st ed. 2011

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Textbook of Tinnitus

Aage R. Møller, Berthold Langguth, Dirk DeRidder, Tobias Kleinjung

ISBN-10: 1607611449

ISBN-13: 978-1607611448

Springer

Groundbreaking, comprehensive, and developed by a panel of leading international experts in the field, Textbook of Tinnitus provides a multidisciplinary overview of the diagnosis and management of this widespread and troubling disorder. Importantly, the book emphasizes that tinnitus is not one disease but a group of rather diverse disorders with different pathophysiology, different causes and, consequently, different treatments. This comprehensive title is written for clinicians and researchers by clinicians and researchers who are active in the field. It is logically organized in six sections and will be of interest to otolaryngologists, neurologists, psychiatrists, neurosurgeons, primary care clinicians, audiologists and psychologists. Textbook of Tinnitus describes both the theoretical background of the different forms of tinnitus and it provides detailed knowledge of the state-of-the-art of its treatment. Because of its organization and its extensive subject index, Textbook of Tinnitus can also serve as a reference for clinicians who do not treat tinnitus patients routinely.

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